About

Hi, I’m Zach Charlop-Powers#

I am a bioinformatic scientist working at Zymergen following the recent acquisition of Lodo Therapeutics. For the last few years I have been working at the interface of metagenomics and drug discovery, using the genomic content of eDNA to mine for new gene-combinations that encode new chemicals.

Publications#

A full list of my papers is avaiable on Google Scholar. Here are a few representative papers.

• Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens. 2018. Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF. Nature Microbiology
• Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity. December 2016. Charlop-Powers Z, Pregitzer CC, Lemetre C, Ternei MA, Maniko J, Hover BM, Calle PY, McGuire KL, Garbarino J, Forgione HM, Charlop-Powers S, Brady SF. PNAS
• Discovery of MRSA active antibiotics using primary sequence from the human microbiome. 2016. Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF. Nature Chemical Biology
• Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast. September 2016. Kang HS Charlop-Powers Z Brady SF. ACS Synth Biol
• Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. 2015. Montiel D, Kang HS, Chang FY, Charlop-Powers Z, Brady SF. PNAS
• Global biogeographic sampling of bacterial secondary metabolism. 2015. Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Guimaraes DO, de Frias UA, Pupo MT, Seepe P, Feng Z, Brady SF. Elife